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Health is wealth - a famous proverb that almost everyone has heard of but may not have fully understood its essence. Health comes from maintaining cleanliness and hygiene which starts from home and expands to workplaces and public areas. By practicing hygiene in the home and everyday life settings, it will have impact significantly in reducing the global burden of infectious diseases that kills over 17 million people a year. Mainly caused by microorganisms, infections can easily spread by direct and indirect contact. Common infectious diseases include chickenpox, common cold, malaria and pertussis. These diseases tend to have specific symptoms such as fever, diarrhoea, fatigue and muscle aches. In institutional settings, such as schools and child-cares settings, information relating hand hygiene is routine. However, the home environment is one of the potential sources of transmission of infectious diseases. This situation, of course, needs to be re-evaluated and the promotion of home hygiene should be encouraged. Positive correlation has been found between home hygiene practices and risk of disease transmission in homes where the first line of defence against infectious diseases is cleaning and disinfecting plus maintaining good hand hygiene. But, the implementation for an effective policy to monitor home hygiene is rather complex due to varying determinants of health. In a nutshell, proper home hygiene and cleaning practices lead to reduced risk of spreading infectious diseases. They should form the key issues in the practice of health promotion in the community and institutions.